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MOTS-c appears to be one of the most potent natural activators of this cascade [1]

Additional information Competing interests The authors declare that they have no competing interests that would influence the content of this review

[oai_citation:4PubMed]( [oai_citation:5PMC]( 4) Growth-hormone receptor (GHR) expression in tendon fibroblasts Gene-expression and protein studies found dose- and time-dependent up-regulation of GHR

Transdermal, vaginal, or other non-oral HRT formulations bypass the gastrointestinal tract entirely, eliminating this potential concern

middle-aged/older) GLP-1 cycling - which leads to weight-cycling (linked to muscle and bone loss) - 1/3 to 1/2 of US adults go on/off/on etc