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Clinical considerations for specific populations: Individuals with diabetes should consult their GP or diabetes specialist before making significant dietary changes, as alterations in carbohydrate intake and meal timing may affect blood glucose control and medication requirements Those taking insulin or sulfonylureas should be particularly cautious, as dietary changes may increase the risk of hypoglycaemia [15] [16] Those with kidney disease should seek medical advice before substantially increasing protein intake People with digestive disorders (such as irritable bowel syndrome) may need to modify fibre recommendations based on individual tolerance Seek urgent medical attention for severe abdominal pain (especially if radiating to the back), persistent vomiting, blood in stool, or symptoms of hypoglycaemia or hyperglycaemia

Appetite suppression Dual GIP/GLP-1 activation provides stronger hunger control than GLP-1 alone

Yerba mate may help prevent infections from bacteria, parasites, and fungi

Study characteristics are detailed in Tables 1 and 2

Serum uric acid is associated with incident metabolic syndrome independent of body shape index and body roundness index in healthy individuals