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Interestingly, while oxyntomodulin-bound GLP-1R displayed a more similar TMD conformation to that bound to GLP-1 in the static cryo-EM structure, the effect of mutagenesis was more divergent, with numerous mutations differentially impacting oxyntomodulin affinity and/or signalling data relative to GLP-1 (Fig
CI = confidence interval, NAC = neoadjuvant chemotherapy
Wiviott SD, Raz I, Bonaca MP, Mosenzon O, Kato ET, Cahn A, Silverman MG, Zelniker TA, Kuder JF, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Ruff CT, Gause-Nilsson IAM, Fredriksson M, Johansson PA, Langkilde A-M, Sabatine MS
Thromb Res 195:1620 Zuchi C, Tritto I, Carluccio E, Mattei C, Cattadori G, Ambrosio G (2020) Role of endothelial dysfunction in heart failure
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