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TabeY, Harada M, Miyamae Y, Mogushi K, Kazuno S, Fujimura T, Matsushita H, Ueno T, Yokomizo T, Miida T, Samudio I, Andreeff M , Konopleva M
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Glutathione is a compound made by the body that protects cells and tissues from damage by free radicals
Glutathione, a tripeptide antioxidant present in hepatocytes, rapidly binds NAPQI through glutathione S-transferase enzymes, neutralizing its toxicity
This raises the possibility that tamoxifen-induced degradation of CIP2A occurs through increased 4HNE formation leading to PP2A activation
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