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discontinue or reduce dose if serum copper exceeds 150 mcg/dL 9 Symptom-based alerts: New-onset muscle pain, dark urine, or unexplained fatigue should prompt immediate CK and hepatic panel measurement Nausea, jaundice, or right-upper-quadrant pain could indicate hepatic copper accumulation or statin hepatotoxicity and warrants urgent evaluation Topical GHK-Cu: A Different Risk Profile Most dermatologic applications of GHK-Cu involve topical serums at concentrations of 0.01-1%

NAC has shown benefit as adjunctive therapy in some trials

2017;37:BSR20160470

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