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[4] PMC (2015)

PMID: 6 NaharciMIKaradurmusNDemirOBozogluEAkMDorukH

Theoretical risks of sustained angiogenic stimulation (promoting vascular supply to undetected pathological tissue) grow proportionally with the duration of use, as cumulative VEGF upregulation exceeds the controlled, injury-localized window intended by short-cycle research protocols