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They are neutralised by glutathione, lowering inflammation and stopping breakouts

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10.2337/db17-1212 190

Further, the appetite-suppressing effects of CCK are blocked with ablation of right vagal afferents, neurons in the lPBN and substantia nigra, and antagonism of D1R/D2Rs in the dorsal striatum [106], suggesting overlapping central mechanisms of CCK with RYGB