glp 1 and ketosis Beyond GLP-1 Agonists: An Adaptive Ketogenic–Mediterranean Protocol to Counter Metabolic Adaptation in Obesity Management GLP-1 Therapy Part 1: Setting

doi: 10.1016/j.eclinm.2021.100979 99 GorelikYGhersinILujanRShlonDLoewenberg WeisbandYBen-TovAet al

Given this broad range of activities, it makes sense that glutathione depletion is associated with disease and agingand that increasing glutathione levels is not only a smart move for health maintenance, but also an effective therapy for a host of serious diseases

Acetyl L-Carnitine shuttles acetyl groups and fatty acids into mitochondria for energy production.* It is also used to make the important brain chemical acetylcholine.* Some studies suggest Acetyl L-Carnitine can even act as a neurotransmitter itself.*

Of note, GLS1 inhibition causes an elevation of the ROS level and induces GPT2 expression via ATF4, which again implies the importance of ATF4-mediated metabolic adaption during glutamine starvation

[5,6] Additionally, the alpha 1-adrenergic receptor, located in the pineal gland, has emerged as a potential target in DSIP-related research