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Thus, in mice, significant antihyperglycaemic effects of DPP-4 inhibition are still apparent in animals lacking the GLP-1 receptor (43), while in clinical studies, GLP-1 receptor antagonism (using exendin 9-39) eliminates only approximately half of the glucose-lowering effect in patients with T2DM treated with DPP-4 inhibitors (44, 45)
10.3389/fendo.2021.626359 135 SongI.ShinH
By acting on receptors in the brain that control hunger and fullness, Semaglutide GLP-1 helps reduce appetite and cravings while slowing down the rate at which food leaves the stomach
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