In case you forgot or have never really been sure what antioxidants are exactly, they are the vitamins and minerals used to fight oxidative stress in the body (oxidative stress causes free radicals to damage our cells by stealing their electrons)
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The 2014 Richie RCT and 2023 Gaike trial used plain reduced glutathione and still produced meaningful biomarker shifts so the choice between advanced-delivery and reduced ultimately comes down to budget, protocol intensity, and your own absorption response rather than a binary better/worse call
There was no change in Thymine-DNA glycosylase (Tdg) mRNA level
Any combination approach would be considered experimental and would require careful medical supervision and monitoring