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Thats especially important for PIs building proof-of-concept work

It is the same logic as a loading phase followed by a maintenance phase in many research protocols: front-load to establish, then hold with less

This would need to be followed by 100 to 1,000 mcg administered by injection every one to three months

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Examples of such a stimulus include presentation of a cue previously paired with the delivery of an addictive drug, presentation of an acute stressor, or acute administration of the addictive drug