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Besides the interleukin family, other genes related to the skin inflammatory mechanism were also upregulated

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77 Clegg LE, Penland RC, Bachina S, Boulton DW, Thuresson M, Heerspink HJL, et al

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Distinct pathological features, including differences between glomerular and tubular injury in the kidney, lobular and periportal inflammation in the liver, and depot-specific inflammatory responses in adipose tissue, complicate the design of broadly effective therapeutic strategies [517,518,519]