For example, a Cleveland Clinic study from June 2025, involving 7,881 participants, found that high-dose tirzepatide users lost 18.0% of their body weight in one year, semaglutide users lost 13.7%, and those who discontinued early (within three months) lost just 3.6%
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Instead, the arrival of oral GLP-1s is likely to attract needle-hesitant patients, effectively expanding the total addressable market (TAM) rather than displacing the existing one
5 Biodistribution Compound concentrations are typically determined in serum or plasma, although the systemic circulation is not necessarily the pharmacodynamic target compartment