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Although almost all tissues in the body have some ability to metabolize chemicals, smooth endoplasmic reticulum in the liver is the principal "metabolic clearing house" for both endogenous chemicals (e.g., cholesterol, steroid hormones, fatty acids, proteins) and exogenous substances (e.g., drugs, alcohol)

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A 2021 stability study published in the International Journal of Pharmaceutics found that reconstituted glutathione stored at 8C retained 92% potency at 28 days, but only 78% potency at 35 days, and 61% potency at 42 days

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