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This distinction is particularly useful in experimental designs where separation of adipose-specific signaling from systemic endocrine effects is required

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Moreover, an oral GLP-1 and amylin co-agonist (amycretin) is also in early phase clinical trials (Table 1)

Observed outcomes include specific cellular and molecular endpoints such as: Enhanced fibroblast migration capacity Increased collagen and elastin deposition Modulation of pro-inflammatory and antioxidant mediators Altered transcriptional profiles related to tissue homeostasis, repair signaling, and stress response All reported observations derive exclusively from preclinical laboratory and animal studies and remain model-specific

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