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From a clinical perspective, the main consideration with retatrutideand potential concernis therefore not the proportion of lean mass lost, but the absolute amount
Additionally, the intestinal tissue has an unstirred water layer (UWL), which is a stagnant water barrier formed between the intestinal villi surface and water molecules, significantly affecting the permeability of lipophilic compounds [8]
It also helps many patients eventually reduce their tirzepatide or semaglutide dose or discontinue it entirely without regaining weight
Mounjaro EPAR Assessment Report Variation (PDF)
Tirzepatide can therefore be seen as an effective and safe treatment option in Japanese people with T2D
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