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Bibcode:1984TetL...25..839B
The goal is to reach the FDA-approved maintenance dose, but holding at a submaximal level is preferable to discontinuation" [10]
This overload of calcium ions causes a decrease in mitochondrial membrane potential and the opening of the mitochondrial permeability transition pore (mPTP), which is a non-specific channel situated between the inner and outer mitochondrial membranes (He et al., 2008
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Increasing the dosage slowly can also help reduce nausea over time
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![PDF] Resistance is not futile: gliotoxin biosynthesis, functionality and utility](https://figures.semanticscholar.org/d953f87324c0b9375a3223a5c1492bfc5c829db3/2-Figure1-1.png)
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