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Importantly, formulation efforts emphasize stability under physiological conditions and resistance to fibril formationa limitation of earlier analogues such as pramlintide (Kruse et al

1 Although oral and perioral pigmentation may be physiologic in nature, particularly in individuals with a darker complexion, throughout the course of disease it is possible for the oral mucosa and perioral tissues to assume a variety of discolorations, including brown, blue, gray, and black

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71 Giugliano D, Maiorino MI, Bellastella G, Longo M, Chiodini P, Esposito K