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This hypothesis, while speculative, could explain the peptides ability to normalize both deficiency and excess states across diverse neurotransmitter disturbances

J Endocrinol (2017) 232:R67r81

Xie Y, Liang B, Meng Z, Guo R, Liu C, Yuan Y, et al

This work is also funded by Japan Agency for Medical Research and Development (AMED-LEAP, grant# 23gm0010006h0005 (T.M.)), the Research Grant by Gutenberg Circle, Strasbourg (T.M.) and Japan Society for the Promotion of Science (Grants-in-Aid for Scientific Research KAKENHI, grant# 21H05122 and 23H02684 (S.A.))

10.1054/mehy.1997.0655 316 StumvollM.MeyerC.PerrielloG.KreiderM.WelleS.GerichJ