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[3,4] However, at 15 g doses of l-citrulline, a lower fractional absorption rate and plasma retention of l-citrulline was observed, potentially due to saturation of its transporters (e.g., ASC or B0,+-amino acid transporters) or reduced renal conversion of l-citrulline to l-arginine

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doi:10.1016/j.juro.2007.10.063 4

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Srenson's thinking was coloured by the fact that a previous drug, Redux, approved in 1996 by the FDA for weight loss and launched with great fanfare, had to be withdrawn a year later after it was found to cause major heart attacks and to be largely ineffective