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This is not a formulation failureit's the intended mechanism for conditions where local intestinal anti-inflammatory action is the therapeutic target

This momentum in drug development for MASH underscores a growing need for translatable preclinical models that accurately reflect human MASH pathology, support mechanistic insights, and predict treatment responses for streamlining the transition from preclinical to clinical development

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Chronic Kidney Disease (CKD)

However, the clinical effects gradually diminish during this period and are generally minimal by the end of this timeframe