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GHK-Cu is the most-studied component for skin biology research, and the addition of BPC-157 (angiogenesis) and TB-500 (cell migration) supports the broader skin-research mechanisms

However, phase 1 clinical trials in patients with locally advanced non-small cell lung cancer and pancreatic cancer showed suboptimal compliance with the diet, indicating challenges in practical application

Tumor necrosis factor-alpha (TNF-alpha), a cytokine involved in systemic inflammation, along with matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) enzymes that break down extracellular matrix proteins might potentially influence both the inflammatory processes and the remodeling of tissues

10.1186/s13059-024-03464-8 14 GongL.ShenX.HuangN.WuK.LiR.LiuY.et al (2024)