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NRP1 binds to S1 through a multi-basic furin-cleavage site (FCS) and promotes S1 shedding to expose the S2 site for TMPRSS2 priming 64
What has been slower to emerge is a framework that recognizes these not as independent problems but as coordinated consequences of a single underlying disruption: the withdrawal of hormonal signals that had, for decades, been quietly governing cellular energy regulation, inflammatory tone, and tissue maintenance throughout the body
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