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Glucagon-like peptide-1 (GLP-1) receptor agonists, including semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda), have become widely prescribed for type 2 diabetes management and weight loss

doi: 10.1089/ars.2012.5149 250 BiswasSK

J Neurochem 37: 730734

This approach has been successfully applied in IMMU-110, which contains a cleavable acyl hydrazone linker formed by reaction between the hydrazide of 4-maleimidomethyl cyclohexane-1-carboxylate (MCC) and the keto group of doxorubicin

Over the last few years, GLP-1 medicines have evolved rapidly from daily injections to once-weekly injections and even oral tablets