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This differential regulation allows therapeutic benefits without common side effects associated with NO manipulation

Table 1 provides a comprehensive overview of the characteristics of the most commonly used GLP-1 RAs [12, 20]

Another study a meta-analysis and review of 78 trials involving more than 73,000 participants concluded that semaglutide was associated with an increased incidence of NAION but emphasized that evidence for a causal link remains inconclusive

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Kitzman DW, Brubaker P, Morgan T et al (2016) Effect of caloric restriction or aerobic exercise training on peak oxygen consumption and quality of life in obese older patients with heart failure with preserved ejection fraction: a randomized clinical trial