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A 2025 study found that statins increased the relative risk of Alzheimers by 20-30% in everyone except for APOE E4/E4 carriers.[ref] A trial that looked specifically at APOE4 and statins found no benefit for statins plus evolocumab (a monoclonal antibody).[ref] Another study using just evolocumab to reduce cholesterol also found no difference in cognitive decline compared to placebo.[ref] However, some studies show that statins may be beneficial

Endogenous GLP-1 alters postprandial functional connectivity between homeostatic and reward-related brain regions involved in regulation of appetite in healthy lean males: a pilotstudy

Notably, 18.4% of participants achieved 20% or greater total body weight loss

9 Insulin is regarded as the metabolic anabolic hormone given its effects on target tissues, whereas glucagon is regarded as the metabolic catabolic hormone

While no foods are off limits, you may need to reduce your consumption of certain foods