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A short history of GLP-1s In 1987, researchers discovered a hormone derived from the gut that supported insulin release to manage blood sugar levels known as glucagon-like peptide 1 (GLP-1)

Because the release stays pulse-like rather than a constant flood, the body's own feedback loops are largely preserved, which is part of why this combo is considered a more physiologic approach than synthetic HGH

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Instead of being a signal of meal initiation, this increase can instigate processes in the CNS which prepare the body to receive and process incoming nutrients appropriately