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Exploiting ferroptosis vulnerabilities in cancer

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In this regard, females exhibit increased susceptibility to autoimmune disease development whereas males show increased susceptibility to non-reproductive malignant cancers ( Steroid hormones signal through their cognate steroid hormone receptors, NR3 class nuclear receptors that share similar structures, including an N-terminal transactivation domain, a highly conserved central DNA binding domain, and a C-terminal ligand-binding domain ( Several reviews have thoroughly described the roles of steroid hormones in regulating intracellular metabolic pathways and immune cell development, activation, and function separately, but they rarely connect the two ( 2 Metabolic reprogramming in immune cells Immune cells play a pivotal role in protecting us from disease and in maintaining tissue integrity during conditions of homeostasis

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