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10.1007/978-3-642-17214-4_14 82 NakanishiT.ShimazawaM.SugitaniS.KudoT.ImaiS.InokuchiY.et al (2013)

A review published in JAMA Ophthalmology detailed nine cases where patients experienced significant vision problems after taking these drugs

The FDA prescribing information includes a boxed warning about thyroid C-cell tumors observed in animal studies

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It also minimizes the activity of free radicals in the body, preventing the activation of melanin-producing enzymes