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doi: 10.1096/fj.07-102731 286 SafaiyanS.Besson-GirardS.KayaT.Cantuti-CastelvetriL.LiuL.JiH.et al

While some individuals may experience the effects for several weeks, others may find that the benefits wear off sooner

Although, as I've mentioned, BPC-157 is free of side effects at normal dosages, I can tell you that the first time I used it, I accidentally dosed with 2500mcg instead of the 250mcg I planned to initially trial with, and I felt for about the next four hours what I would best describe as a slight amount of irritability and grumpiness, which was likely due to the anabolic cortisol response from a very minor overdose

Patients with Active Psychiatric Conditions Given BPC-157's documented effects on dopamine and serotonin systems, patients with bipolar disorder, schizophrenia, or active major depressive disorder on psychoactive medications represent an unstudied population where caution is warranted

His central insight: don't try to deliver the molecule, give the cell what it needs to build the molecule itself