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In order to facilitate robust adhesion and/or transendothelial migration, these molecules interact with counter-receptors present on leukocytes and plasminogen activator inhibitor-1 within the circulatory system, indicating the potential presence of an endothelial phenotype that is both pro-inflammatory and pro-thrombotic (90)

Age may also be a potential confounder as serum glutamate was elevated in adults with autistic disorder compared to adult controls [75] but was not significantly different in children with autistic disorder compared to child controls [69, 70]

All preclinical safety information comes from animal studies, which may not fully predict human responses