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And it's precisely why a therapy that builds new blood supply directly into damaged tissue can change the equation when nothing else has

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When bypassed via injection, or when very high concentrations are used topically over large surface areas, this regulatory mechanism is skipped

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Doctors sometimes recommend a very low-calorie diet (under 1,000 calories per day) if someone is obese and has a medical condition, such as high blood pressure, but these diets must be carefully supervised by a doctor