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In diet-induced obese mice, chronic Retatrutide dosing produced greater reductions in adipose mass and food intake than matched-exposure Semaglutide or Tirzepatide comparators, with indirect calorimetry showing increased energy expenditure attributable to the GCGR component and reduced hepatic triglyceride content on histology
Jens Juul Holst, a Danish GLP-1 expert at the University of Copenhagen, later recalled Engs frustration to Science magazine in 2018: He was extremely frustrated
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