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The LEAD-1 study provided clinical input and compared glimepiride with two doses of liraglutide (1.2 mg and 1.8 mg) and rosiglitazone (4 mg) in patients with type 2 diabetes mellitus (T2DM) (16)

Therefore, l-ARG supplementation might be regarded to as a potential alternative approach in a variety of clinical settings, spanning different therapeutic requirements in the management of ED

Several theories exist: The additive effects theory suggests that GIP and GLP-1 work through partially independent pathways

This finding is particularly significant given that some trials extended to 24 weeks of continuous exposure and included individuals with obesity-related health conditions who might have higher baseline health risks

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