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We observed a significant decrease in MMP-2 activity and a significant increase in MMP-9 activity in GGC-treated cells, suggestive of the differential effect of GGC and increased GSH on MMPs

The phase 3 TRIUMPH-4 data showed these rates at 9 mg and 12 mg doses respectively: Nausea: 38.1% and 43.2% (vs 10.7% placebo) Diarrhea: 34.7% and 33.1% (vs 13.4% placebo) Constipation: 21.8% and 25.0% (vs 8.7% placebo) Vomiting: 20.4% and 20.9% (vs placebo) These numbers are higher than cagrilintide monotherapy across the board

Hammes, H

Research on combination approaches remains limited, but the distinct delivery pathways suggest potential synergy

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