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While the peptides activation of ENC-alpha in the lungs is a good thing in pneumonia where fluid literally interferes with breathing, the investigators were concerned that activating ENaC-alpha in the kidneys might disturb normal sodium retention, which is important to the kidneys role in blood pressure regulation

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Mistake 1: adding water too fast Squirting bacteriostatic water directly onto the lyophilized powder creates foam and mechanical stress that can denature the peptide

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