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How to Supplement B12 if You Have MTHFR For those with an MTHFR mutation, standard B12 supplements like cyanocobalamin may not be the most effective option

Because that concept, scientifically, made sense, the compound advanced into human clinical trials

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[1] However, because B12 is water-soluble, the body typically eliminates excess amounts through renal excretion without adverse effects

Vitamin B12 in human colostrum and milk: quantitation of the vitamin and its binder and the uptake of bound vitamin B12 by intestinal bacteria