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Metformin enhances antitumor action of sodium dichloroacetate against glioma C6

Injectable formulations are typically initiated at low doses (0.25 mg weekly for Ozempic/Wegovy) and gradually titrated upward to minimize gastrointestinal side effects, which are among the most common adverse reactions

For example, though Ahr can inhibit CD4 + T cells function and support Tregs differentiation [142], it promotes the antimicrobial activity of macrophages and both CD8 + T cells and NK cells-mediated cytotoxicity [132, 135, 143,144,145]

For older adults or those with coronary artery disease, lower starting doses with gradual titration are recommended
