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Funding This study was supported by the National Natural Science Foundation of China (82260459, 82303342, 82203075, and 82460600), the Natural Science Foundation of Jiangxi Province (20224BAB216068 and 20212BAB216029) and the Health Commission science and technology plan project of Jiangxi province (202210033)

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Dual inhibition of sglt2 and dpp-4 promotes natriuresis and improves glomerular hemodynamic abnorMalities in kk/ta-ins2(Akita) mice with progressive diabetic kidney disease

This creates a cycle where weight gain leads to more inflammation, and that inflammation makes it harder to lose the weight