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Although the results obtained from these preclinical models translate to humans, different mechanisms exist in animals and humans, the investigation of which is a topic for future studies
The comparison between phentermine and semaglutide , phentermine and tirzepatide , and phentermine and GLP-1 medications broadly consistently shows the GLP-1 class producing greater weight loss with a more favorable long-term safety profile
GLP1/E therapy led to upregulation of pathways involved in autophagy and vesicle-mediated transport, suggesting that this intervention enhances hypothalamic autophagy, a mechanism that may contribute to the metabolic improvement observed in GLP1/E-treated animals
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