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Cytosolic synthesis of GSH takes place in two ATP-dependent reactions catalyzed by glutamate-cysteine ligase (GCL) and glutathione synthase (GS)

then a 20 mg/kg dose (the typical therapeutic dose) produces a gut concentration of 6000 M, assuming 75% bioavailability

For many users, this convenience outweighs potential advantages of alternative treatments

1 Nausea was the most common adverse event, affecting about 55% of CagriSema participants versus 12.6% on placebo

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