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Activation of these receptors in the brain (particularly brainstem and hypothalamic regions) suppresses appetite, reduces food intake through both homeostatic and hedonic pathways, slows gastric emptying to prolong fullness, and inhibits postprandial glucagon release to aid glucose control

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Regarding biological properties, ferroptosis cell death is associated with the formation of reactive oxygen species (ROS), evidenced mainly by iron and lipid peroxidation buildup

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