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Conversely, recent studies have suggested that phase I participates to the modulation of the olfactory signal through synthesis 5,6 of active phase I metabolites 7,8,9

These reports prompted regulatory agencies in multiple countries to investigate whether a causal relationship exists between these medications and suicidal thoughts or behaviors

Research shows it interacts with dopamine, serotonin, GABA, and nitric oxide systems

S2CID 229692736

This finding is clinically significant: the individuals who respond most strongly to afamelanotide are the same individuals whose baseline pigmentation provides the least UV protection