Copper is required for activity at the cellular receptor level, and the copper ion is what makes the molecule a meaningful regulator of matrix metalloproteinases and their tissue inhibitors 2
Upon binding to IGF, IGF-IR undergoes changes in its conformation, which in turn abolishes the restraints of intrinsic kinase activity by the ectodomain, and triggers transphosphorylation of its tyrosine kinase domains [29]
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Stability Information Freeze for storageRefrigerate after reconstitutionProtect from light Lyophilized (powder) -20C 24+ months Reconstituted 2-8C ~30 days For Research Use Only Products are intended solely for laboratory and scientific research purposes
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