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It has been reported that 8-hydroxy-2deoxyguanosine buildup causes DNA damage
In addition, it has been debated whether erythrocyte membrane injury could promote the thrombotic complications frequently observed in COVID-19 patients [342], and that reduced deformability of erythrocytes may contribute to inflammation and hypoxia in COVID-19 patients [343]
Typically this type of decision would be made by those same career staff members
if anything, tolerability concerns argue for going slower
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