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Rare heterozygous PCSK1 variants in human obesity: the contribution of the p.Y181H variant and a literature review

Adults with an overweight BMI of 27 kg/m 2 or greater with at least one weight-related health condition, such as high blood pressure, high blood sugar, or high cholesterol

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Semaglutide (Ozempic/Wegovy) raises resting heart rate by approximately 14 bpm, and tirzepatide (Mounjaro/Zepbound) by approximately 24 bpm