Frias JP, Nauck MA, Van J et al (2018) Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial
International Journal of Molecular Sciences, 14 (2), 36393655
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As we already mentioned, the difference between "twice a day" and "every 12 hours" can be very impactful, even if the patient doesn't know why
1 Baker J, Hardy MP, Zhou J, Bondy C, Lupu F, Bellve AR, Efstratiadis A: Effects of an Igf1 gene null mutation on mouse reproduction