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Structure 3 , 11091119 (1995)

Although oral therapy with the least toxic of these compounds, glutathione monoethyl ester, did raise erythrocyte and white blood cell glutathione levels in a few affected patients (W Rhead, unpublished results), it also provoked moderate gastrointestinal irritation resulting in vomiting and diarrhea, largely precluding oral therapy with this compound or other related molecules containing free sulfhydryls

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These changes are mainly cosmetic, but they can feel surprising or upsetting, especially when youre otherwise happy with the effects of the medication. Not everyone who uses GLP-1 medications will experience changes like Ozempic vulva, and you may not be able to prevent them entirely