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JNK/Bim, Wnt/-Catenin, PI3K/AKT and ERK/TFEB signaling pathways have been demonstrated to modulate TECs apoptosis in DKD (114117)

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Although interventions such as antihypertensive therapy and valve replacement can resolve chronic cardiac injury, they often fail to reverse the myocardial fibrosis process, suggesting that the fibrogenic process may become self-sustaining

Introduction Maintenance of mitochondrial function and mitochondrial adaptation to changes in nutritional state is vital for the preservation of pancreatic -cell regulated secretion of insulin 1 , the main hormone in charge of lowering blood glucose concentrations, with disruptions in this process underlying the development and/or progression of type 2 diabetes (T2D) 2, 3 an uncontrolled pandemic affecting ~500 million people worldwide, and causing ~1.5 million deaths per year 4

Glutamate and GABA in Autism Spectrum Disordera Translational Magnetic Resonance Spectroscopy Study in Man and Rodent Models. Translational Psychiatry, vol