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Infusion of 5-MTHF improved the impaired endothelium-dependent vasodilation in patients with familial hypercholesterolemia [201], diabetes [25], and coronary artery disease [27]
These mediators collectively drive the process of secondary neurological injury by activating endothelial cells, recruiting immune cells, and disrupting the BBB
Wang Y, Dubland JA, Allahverdian S, Asonye E, Sahin B, Jaw JE, et al
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Most strikingly, IC 50 values to lower cholesterol accumulation in NPC1 mutant cells for three of the four compounds ( 3 , 6 , 10 ) were in the mid-nanomolar to low-micromolar range
Biology, 12 (2), 279
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